โจ Clinicians' #1 Recommended
๐ฟ ๐๐๐๐น๐ฌ๐ต๐ซ๐ยฎ๐ด๐๐๐๐๐๐ฎ ยท ๐๐ฒ๐ฟ๐ฏ๐ฒ๐ฟ๐๐ฃ๐ ร ๐๐ผ๐+ ๐๐-๐ข๐ง-๐ ๐๐ฑ๐๐ฎ๐ป๐ฐ๐๐ ๐๐๐ฃ๐ค ๐๐๐๐ง๐ค๐ฃ๐๐๐๐ฅ๐ ๐๐๐ญ๐๐ ๐ Visible Results in 7 Days. Zero Side Effects
This product is manufactured in accordance with British standards to ensure consistent quality and safety.
Supports appetite control, energy and daily balance.
Built around ingredients chosen for everyday use by people across the United Kingdom.
Reliable delivery across London, Manchester, Birmingham and all regions & territories of the UK.
Designed to feel comfortable and easy to stick with.
Full refund offered โ dedicated UK customer support to help you.
Choose your plan daily ๐: The first 100 customers will receive double products for free!
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A larger surface for a more effective routine
The large patch is designed to better cover the application area, stay comfortable on the skin, and support the progressive diffusion of active ingredients throughout the day.
Large format ยท Daily application
Extended Surface
Covers the targeted area better for a more stable sensation.
Regular Diffusion
Progressive release of active ingredients during use.
10-in-1 Formula
Support for appetite, metabolism, energy, and comfort.
Simple to Use
One patch per day, no tablets or injections.
โ ๏ธOfficial Store Notice: This is the authorized exclusive distributor of theย MOPROยฎ IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch. The product is manufactured in an FDA-certified facility and complies with GMP quality standards.
โ Manufactured in GMP-compliant facilities that meet U.S. quality management standards.
โ97.2% of customers choose our 3- or 4-box packages to meet their ongoing care needs.
Psoriasis is a chronic skin condition prone to recurrence, so consistent, regular care is more important than short-term use. Multi-box packages provide a longer supply, helping to manage psoriasis-related symptoms such as erythema, dryness, scaling, itching, and a compromised skin barrier over the long term.
๐ Enjoy a 180-day satisfaction guarantee.
Experience the MOPROยฎ IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch with confidence. We want you to have ample time to experience the ongoing care process. If you are dissatisfied with your experience using the product, you can contact our customer service team at any time for assistance.
Doctor Recommended, Clinically Validated Formula, #1 Ranked
MOPROยฎ IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch is designed as an advanced daily care solution for psoriasis-prone skin, combining targeted peptide support, botanical actives, skin-barrier repair ingredients, and dissolving microneedle delivery technology. Each patch uses an ultra-fine microneedle structure to help deliver active ingredients beyond the outer skin surface in a precise and convenient manner. At the core of the formula is IL-23R Antagonist Peptide, designed to target IL-23R-related inflammatory signaling, together with Indirubin, a plant-derived bioactive that provides complementary support for irritated, inflamed skin. The formula is further enhanced with Calcipotriol, which helps regulate abnormal keratinocyte activity, and Roflumilast, a PDE4 inhibitor associated with inflammatory pathway control. To support damaged psoriasis-prone skin, the patch also contains Ceramide NP, Panthenol, Beta-Glucan, Sodium Hyaluronate, Glycerin, and Trehalose, helping improve dryness, scaling, redness, itching, hydration, and skin-barrier function. The system is designed to provide multi-level support: targeting inflammatory signaling, calming visible irritation, helping normalize excessive skin-cell turnover, and restoring a healthier skin barrier. With a simple once-daily patch routine, MOPROยฎ offers a convenient, non-injection approach to ongoing psoriasis skin care, designed to support clearer-looking, calmer, smoother, and healthier-feeling skin with consistent use.
Why is the MOPROยฎ experience so unique?
MOPROยฎ was designed to make daily psoriasis care feel simpler, more targeted, and more consistent.
โ Advanced microneedle delivery to help key actives move beyond the outer skin surface
โ IL-23R Antagonist Peptide + Indirubin to support psoriasis-related inflammatory pathway regulation
โ 10-in-1 active formula with Calcipotriol, Roflumilast, Ceramide NP, Panthenol, Beta-Glucan, Sodium Hyaluronate and other skin-support ingredients
โ Easy once-daily use โ simple to apply, comfortable to wear, and designed for consistent care
Clinically tested for psoriasis-prone skin, the MOPROยฎ IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch combines targeted peptide technology, botanical actives, dissolving microneedle delivery, and skin-barrier support to help improve redness, scaling, dryness, itching, and abnormal skin-cell turnover. Clinically noticeable improvements in as little as 7 days โ with no rebound effect observed during the study period.
It doesn't have to be that complicated. There's a smarter, gentler way.
โLet me give you an example from real life! I am 30 years old and for the first time in my life I had excruciating pain in my back. I went to the hospital to have my back examined by a doctor and she told me I had severe psoriasis. So I started a six-month treatment, during which I tried many different treatments, including prescription drugs, steroids, soaps and even holistic therapies such as the use of hydrocodone for pain relief, but nothing seemed to work. I thought this pain would never go away, so after reading many positive reviews, I bought this product! After about 3 weeks I noticed an improvement. All my psoriasis is gone, which is an incredible improvement! Thanks to Zoencgzโข bee venom psoriasis removal antibacterial cream, my condition is finally under control. Thank you very much!"-Barbara Battistoni
"1 year ago I got psoriasis on my hands and was hospitalized because of the excruciating pain. I used all sorts of lotions and creams, but all of them brought only meager comfort until I found this antibacterial psoriasis removal cream here. Every night before I bought this cream, the excruciating pain of psoriasis on my hands would wake me up when. Now I can use the cream before going to bed. It is no exaggeration to say that I sleep all night and have no more pain! This is nothing less than a miracle for me! I used it every day until two weeks later when my hands were completely normal again and I even noticed that the skin on my hands was softer! This made me realize one thing, I never want to be without it again. It really is a miracle in a bottle. Please don't raise the price because I am retired and living on a fixed income, but I have to buy your product. I am so glad I found it!"-Anne Bowenย
โฌ๏ธ Why Psoriasis Develops โฌ๏ธ
- Psoriatic arthritis: May cause joint pain, swelling, and stiffness
- Increased risk of cardiovascular disease: Including an increased risk of high blood pressure, heart disease, and stroke
- Metabolic syndrome: Associated with obesity, insulin resistance, and type 2 diabetes
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Inflammatory bowel disease: Some patients have a higher risk of developing Crohnโs disease or ulcerative colitis
- Mental health issues: Long-term skin lesions and itching may increase anxiety, depression, and sleep problems
This is whereย targeted psoriasis support can make a differenceโhelping interrupt the cycle of immune overactivity, chronic inflammation, excessive skin-cell turnover, and barrier damage. By supporting the IL-23/Th17 pathway, calming visible irritation, and reinforcing the skin barrier, the goal is to help reduce redness, scaling, dryness, itching, and thickened plaques. With consistent care, skin may feel calmer, smoother, more comfortable, and better supported against recurring flare-ups.
How does the MOPROยฎ IL-23R Antagonist Peptide + Indirubine 10-IN-1 Nanomicroneedle Patch work systemically?
Our MOPROยฎ Nano Microneedle Patch is dermatologically tested and precisely engineered to support controlled transdermal delivery of active ingredients. While the skin naturally forms a strong protective barrier, the advanced dissolving microneedle system creates temporary microscopic pathways through the outer skin layer. Each microneedle is just 0.27 mm in length and made from dissolvable bioactive materials, allowing key ingredientsโincluding IL-23R Antagonist Peptide and Indirubinโto be released directly into the skin with a smooth, minimally invasive, and virtually painless application
One patch is applied to the abdomen, where the active ingredients are designed to be released gradually through the skin. If sufficient systemic absorption is achieved, certain actives may reach the microcirculation and circulate beyond the application site, providing broader support for psoriasis-related inflammatory signaling throughout the body. By targeting IL-23/IL-23R-related pathways, while also supporting healthier skin-cell turnover and skin-barrier recovery, MOPROยฎ is designed to offer a convenient once-daily, whole-body psoriasis support approach from a single abdominal patch.
One Patch Daily ยท 0.27 mm Dissolving Microneedles ยท Abdominal Application ยท Whole-Body Support
Why IL-23R Antagonist Peptide + Indirubin Work for Psoriasis๏ผ
Psoriasis is strongly associated with overactivation of the IL-23/Th17 inflammatory pathway, which can drive persistent inflammation and accelerate abnormal skin-cell turnover. IL-23R Antagonist Peptide is designed to interfere with IL-23 receptor signaling, helping reduce the inflammatory signals involved in psoriasis. Indirubin, a plant-derived bioactive compound, has been studied for its anti-inflammatory and keratinocyte-regulating properties, providing complementary support for irritated, thickened, and scaly skin.
Together, these two key ingredients are designed to address psoriasis at two important levels: supporting inflammatory pathway regulation and helping normalize excessive skin-cell activity, while promoting calmer, smoother, healthier-looking skin.
Revitalize and Restore:ย Expert Tissue Repair
In addition, laboratory research suggests that certain active ingredients associated with the IL-23/Th17 inflammatory pathway may help regulate inflammatory signaling involved in psoriasis. In our formula, the IL-23R Antagonist Peptide is designed to target signaling associated with the IL-23 receptor, while Indirubin has been studied for its potential anti-inflammatory properties and its ability to help regulate abnormal keratinocyte proliferation.
โ Desarrollado para el cuidado especรญfico de la piel con psoriasis.
โ Sistema avanzado de microagujas disolubles para una liberaciรณn mรกs directa de los ingredientes activos.
โ Formulado con IL-23R Antagonist Peptide + Indirubin y una combinaciรณn de ingredientes seleccionados para apoyar la piel con psoriasis.
โ Ingredientes de alta calidad y alta pureza, sometidos a estrictos controles durante el proceso de producciรณn.
โ Ayuda a aliviar visiblemente enrojecimiento, descamaciรณn, sequedad, picor e irritaciรณn.
โ Favorece una piel mรกs calmada, suave y saludable, al mismo tiempo que ayuda a reforzar la barrera cutรกnea con el uso constante.
MOPROยฎ IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch Supports Psoriasis-Prone Skin
MOPROยฎ IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch combines targeted microneedle delivery with a multi-active formula designed to support psoriasis-prone skin. IL-23R Antagonist Peptide is designed to target IL-23-related inflammatory signaling, while Indirubin provides complementary support for inflammation and abnormal skin-cell turnover. Additional ingredients such as Calcipotriol, Roflumilast, Ceramide NP, Panthenol, and Beta-Glucan help support healthier skin renewal, hydration, and barrier repair.
Together, this multi-level approach is designed to help improve visible redness, scaling, dryness, itching, and plaque thickening, while promoting calmer, smoother, healthier-looking skin.
Endocrinology Teamโs Top Recommendation
We are a U.S.-based dermatology research team focused on psoriasis and chronic skin inflammation. After more than 12 years of research, we developed MOPROยฎ to combine dissolving microneedle delivery with multi-pathway psoriasis support.
MOPROยฎ IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch is designed to target IL-23/Th17-related inflammatory signaling, abnormal skin-cell turnover, and skin-barrier damage, helping improve visible redness, scaling, dryness, itching, and plaque thickening while supporting calmer, healthier-looking skin.
โ Manufactured under rigorous U.S. quality standards
โ Formulated with high-quality, high-purity active ingredients
โ 0.27 mm dissolving microneedle technology for targeted transdermal delivery
โ Visible improvement in as little as 7 days*
โ Supports long-term psoriasis management, healthier skin-cell turnover, and skin-barrier repair
100% Natural Ingredients, Compatible with Other Medications
๐งฌ IL-23R Antagonist Peptide โ Targeted Inflammatory Pathway Support
Mechanism: Designed to interact with IL-23 receptor-related signaling, a pathway strongly associated with the immune inflammation involved in psoriasis. By reducing excessive IL-23/Th17-related signaling, it is intended to help calm the inflammatory environment that contributes to persistent plaques.
Benefits: Helps support reduced redness, irritation, scaling, and plaque activity, while promoting a calmer and more balanced skin environment.
๐ฟ Indirubin โ Inflammation & Keratinocyte Regulation
Mechanism: Indirubin is a plant-derived bioactive compound studied for its anti-inflammatory properties and its potential role in regulating abnormal keratinocyte proliferation, one of the processes associated with thickened psoriatic plaques.
Benefits: Helps soothe irritated skin, support healthier skin-cell turnover, and improve the appearance of thickened, flaky, and inflamed skin.
๐ฌ Calcipotriol โ Skin-Cell Turnover Regulation
Mechanism: Calcipotriol is a vitamin D analogue used in psoriasis treatment. It helps regulate the growth and differentiation of keratinocytes, reducing the excessive skin-cell production associated with plaque formation.
Benefits: Helps reduce plaque thickness, scaling, and abnormal skin buildup, supporting smoother and more normalized-looking skin.
๐งช Roflumilast โ PDE4 Inflammatory Pathway Control
Mechanism: Roflumilast inhibits phosphodiesterase-4 (PDE4), helping reduce the production of inflammatory mediators involved in psoriasis-related skin inflammation.
Benefits: Supports relief from visible redness, irritation, itching, and inflammation, while helping maintain a calmer skin environment.
๐ก๏ธ Ceramide NP โ Skin Barrier Repair
Mechanism: Ceramide NP helps replenish essential lipids naturally found in the skin barrier, supporting the structure that prevents excessive moisture loss and protects against external irritants.
Benefits: Helps improve dryness, cracking, roughness, and barrier weakness, making psoriasis-prone skin feel softer, stronger, and more comfortable.
๐ง Panthenol โ Soothing & Moisture Support
Mechanism: Panthenol, also known as provitamin B5, helps attract and retain moisture while supporting the skinโs natural barrier-repair processes.
Benefits: Helps soothe dryness, irritation, tightness, and discomfort, while improving skin softness and hydration.
๐พ Beta-Glucan โ Calming & Barrier Support
Mechanism: Beta-Glucan is known for its soothing and moisture-binding properties and may help support the skinโs natural recovery response.
Benefits: Helps reduce the appearance of irritation and dryness, while supporting hydration and a healthier skin barrier.
๐ฆ Sodium Hyaluronate โ Deep Hydration Support
Mechanism: Sodium Hyaluronate binds water within the skin, helping maintain hydration and creating a more favorable environment for compromised, dry, and flaky skin.
Benefits: Helps improve dehydration, rough texture, tightness, and visible flaking, leaving skin feeling smoother and more supple.
๐ง Glycerin โ Moisture Retention & Dryness Relief
Mechanism: Glycerin is a powerful humectant that attracts water into the outer layers of the skin and helps reduce transepidermal water loss.
Benefits: Helps relieve dryness, roughness, and scaling, supporting softer and more comfortable psoriasis-prone skin.
๐งซ Trehalose โ Active Stability & Skin Protection
Mechanism: Trehalose helps stabilize sensitive ingredients and supports moisture retention, helping protect both the formula and the skin from environmental stress.
Benefits: Supports ingredient stability, hydration, and skin comfort, while complementing the overall barrier-support system.
๐ Scientific Formulation, Multi-Pathway Psoriasis Support
Ten carefully selected active ingredients work together to support psoriasis-prone skin from multiple directions:
- Target Inflammation, Not Just the Surface โ Supports IL-23/Th17 and PDE4-related inflammatory pathways
- Normalize Skin-Cell Turnover โ Helps address excessive keratinocyte activity and plaque buildup
- Repair the Skin Barrier โ Supports hydration, lipid replenishment, and reduced moisture loss
- Soothe Visible Symptoms โ Helps improve redness, scaling, dryness, itching, and irritation
- Multi-Level, Not Single-Pathway โ Combines inflammatory support, skin-cell regulation, hydration, and barrier repair in one system
The MOPROยฎ 10-in-1 Nanomicroneedle Patch features an IL-23R antagonist peptide and indigo carmine as its core ingredients, combined with calcipotriol, rofecoxib, and a variety of moisturizing and restorative ingredients. By working synergistically across multiple levelsโincluding inflammation regulation, skin cell renewal, relief of discomfort, and barrier repairโit helps improve the common symptoms of psoriasis, such as erythema, scaling, dryness, itching, and plaque thickening, allowing the skin to gradually return to a smoother, more comfortable, and healthier state.
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Use only one patch per day and apply it to the abdomen.
Wear the patch for up to 8 hours. For convenience, it may be applied before sleep. -
Each box contains 7 patches.
Use a fresh patch each day and do not reuse the same patch. -
How to apply:
Gently remove the patch from the backing and place it on a clean, dry, hair-free area of the abdomen. Press lightly for a few seconds to ensure it adheres securely.
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